Efficacy of MIIP treatment against PRRSV infection in PRRS antibody-negative pigs


Purpose

Assess whether MIIP stimulates the mucosal immunity.

The Objects

4-week-old pigs *16

Condition

16 pigs were randomly divided into two group. Two groups were rearing in adjacent barns. The experiment group supplied with the feed containing 0.02% MIIP; the control group supplied with the equal amount of the feed without MIIP, and conducted for 4 weeks. The PRRS ELISA antibody was detected before and after the trial.

The experiment condition

PRRS ELISA antibody were showing negative before the trial. After four weeks treating, control group turned to positive, but MIIP group remained negative. It may due to the stimulation of mucosal immunity system, generating the specific IgA, which blocked PRRSV from mucosal membrane, and consequently decreased the pathogen stimulation.

The result

Conclusion

The trial demonstrates MIIP could help IgA generation, that block PRRSV from mucosal layer, which decreases the amount of virus crossing the mucosal layer and consequently lowers ELISA antibody titer.

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